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304,308 Practice points Eligibility and pre-surgical assessment Multidisciplinary specialised obesity services provide medically led, multidisciplinary care that incorporates nutrition and physical activity interventions, psychological therapies, pharmacological treatment, and access to metabolic bariatric surgery where clinically appropriate and feasible

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The STEP 4 withdrawal trial demonstrated that discontinuation of semaglutide 2.4 mg after a 20-week run-in is followed by nearly complete weight regain within one year an outcome that is more accurately framed as disease recurrence in a chronic relapsing condition than as drug failure (Quimbayo-Cifuentes, 2026)